Journal: eBioMedicine
Article Title: Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality
doi: 10.1016/j.ebiom.2024.105414
Figure Lengend Snippet: Development of the IFNγ-driven sepsis (IDS) endotype in the discovery set . A) Bar graphs of 28-day mortality in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. The p-value of comparison by the Fisher's exact test is provided. B) Distributions of the absolute count of HLA-DR receptors on CD45/CD14-monocytes in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. C) Distributions of sCD163 in patients with IFNγ more than 3 pg/ml and IFNγ 3 pg/ml or less. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. D) Distributions of CXCL9 in survivors and non-survivors. This comparison involves only the patients with IFNγ levels more than 3 pg/ml. Lines overlying the distributions represent medians and interquartile ranges. The p-value of comparison by the Mann–Whitney U test is provided. Abbreviations: CI, confidence interval; IDS, IFNγ-driven sepsis; IFN, interferon; n, number of patients.
Article Snippet: Samples were transported into a central lab for the measurement of the following proteins: a) IFNγ, IP-10 (Diaclone, Besançon, France), CXCL9, interleukin (IL)-18 and soluble sCD163 (ELK Biotechnology, Denver, USA) with an enzyme immunosorbent assay.
Techniques: Comparison, MANN-WHITNEY
